1/2/2024 0 Comments Safe box with code![]() ![]() So get ready to blast off in a rocket fuelled Starfield performance preview. We also compare the improvements over the previous showing, enhancements within the engine, and much more. Lock box for secure storage of keys Metal body for durability with protective weather cover to prevent freezing Push button access code using up to 12 letters. SLYPNOS 1.0 Cubic Feet Electronic Home Safe - Best Small Safe for Apartment. ![]() Fingerprint and keypad with Manual (key) override. If this happens, wait 10 to 20 minutes, and try again. Depending on the type of keypad, it typically emits a rapid series of beeps. Safe Box: The bodies you see on the floor are the keypad, and the ones with blood are the keys that you’ll need before unlocking. The biggest question after the show(s) was: why is it 30fps on Xbox Series X and Series S and not 60fps? In this IGN Performance preview, we dive into the details shared by the team, the revealed PC minimum and recommended specifications, and how the Creation Engine 2 works, comparing the previous games to gauge some of the potential reasons why the team might have chosen 30fps. 1 In Stock SentrySafe Extra-Large Steel Security Fire Safe Box With Digital Keypad, 34.8-L, Black 4.3 (605) 439.99 Top Rated 046-3524-8 2 In Stock SentrySafe Small Fire Safe Security Chest with Key Lock, Black, 5-L 4.5 (683) 59. TIGERKING Biometric Home Safe - Best Biometric Safe for Home. Many safes go into penalty lockout mode if too many wrong codes are entered. Using this simple trick, you can easily get the code. ![]() With Starfield being the center of the Xbox 2023 Showcase last week, Bethesda gave us a deep dive into one of the biggest games this generation. ![]()
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1/2/2024 0 Comments Duck billed platypus venom![]() ![]() But while the platypus has spurs on its hind limbs for delivering a large amount of venom to its opponent, there is no such spur on echidnas. GLP-1 has also been discovered in the venom of echidnas. ![]() “Excitingly, stable GLP-1 molecules are highly desirable as potential type 2 diabetes treatments.” “The function in venom has most likely triggered the evolution of a stable form of GLP-1 in monotremes.” Briony Forbes, from the University of Adelaide’s Robinson Research Institute and Flinders University’s School of Medicine. “This tug of war between the different functions has resulted in dramatic changes in the GLP-1 system,” said co-lead author Dr. The authors discovered conflicting functions of GLP-1 in the platypus: in the gut as a regulator of blood glucose, and in venom to fend off other platypus males during breeding season. “Further analysis of the genetics of monotremes reveals that there seems to be a kind of molecular warfare going on between the function of GLP-1, which is produced in the gut but surprisingly also in their venom,” he added. “We’ve found that GLP-1 is degraded in monotremes by a completely different mechanism.” Frank Grutzner, from the University of Adelaide’s Robinson Research Institute. “Our team has discovered that monotremes - echidnas ( Zaglossus sp.) and platypus - have evolved changes in the hormone GLP-1 that make it resistant to the rapid degradation normally seen in humans,” said co-lead author Prof. In people with type 2 diabetes, the short stimulus triggered by the hormone isn’t sufficient to maintain a proper blood sugar balance.Īs a result, medication that includes a longer lasting form of GLP-1 is needed to help provide an extended release of insulin. It acts through the GLP-1 receptor expressed in the pancreas, brain and other peripheral tissues.”īut GLP-1 typically degrades within minutes. “GLP-1 potentiates glucose-stimulated insulin secretion from pancreatic beta cells and promotes their survival. ![]() “In humans GLP-1 and gastric inhibitory polypeptide (GIP) are the only known insulin stimulating incretin hormones and are released from intestinal cells after food intake,” the researchers said. It is normally secreted in the gut of both humans and animals, stimulating the release of insulin to lower blood glucose. The hormone in question is called GLP-1 (glucagons-like peptide 1). This image is a digital reproduction of a painting by John Lewin of a platypus in 1808. ![]() ![]() ![]() A Large Room cannot be connected vertically with a Multipurpose room using Ladders or an Alien Containment.The flat roof of a Large Room can be used for placing Exterior Growbeds if the player does not wish to expand vertically.A Large Room Glass Dome can be installed on a Large Room, at great cost to hull strength.A ladder must be built to travel between the rooms. The roof of the bottom Large Room will be the floor of the top Large Room, and Alien Containments will stack like in Multipurpose Rooms. Ladders can be placed where ceiling tiles are located, so long as another Large Room is above the tile.Note that Partition Doors must be built onto existing Partitions. Partitions and Partition Doors can be built along the markings on the floor, as well as attached to walls at wall nodes. ![]() This arrangement works correctly physically, but causes the floor of the upper tank to render strangely. Alien Containments on adjacent floors can be built in a "stair step" configuration, sharing only one floor node.They do not hold extra creatures, however. Alien Containments built in the Large Room will be approximately twice the size of one built in a Multipurpose Room, taking up two floor nodes.The four nodes of this kind are marked by large black tiles. ![]()
1/2/2024 0 Comments Mega man 11 walkthrough![]() ![]() Update to the latest version of Homebrew and try again. If during installation you see an error such as “Error: game-porting-toolkit: unknown or unsupported macOS version: :dunno”, your version of Homebrew doesn’t have macOS Sonoma support. It can take over 1 hour to complete depending on the speed of your Mac.īrew -v install apple/apple/game-porting-toolkit How long this takes will depend on the speed of your computer. This formula downloads and compiles several large software projects. Install the game-porting-toolkit formula. Your shell will now select the right installation of Brew, depending on your architecture. You may now restart your terminal and use the following command to return to an x86_64 shell: Scroll down (by using the arrow keys or Control + V) to the bottom of the file, and paste the following script:Įval "$(/opt/homebrew/bin/brew shellenv)" (Optional) If you want to have both ARM64 and x86 versions of Brew installed, begin by editing your. Optionally retain both ARM64 and x86 versions of Brew If this command does not print /usr/local/bin/brew, you should use this command: Make sure the brew command is on your path: (echo echo 'eval "$(/usr/local/bin/brew shellenv)"') > /Users/$USER/.zprofile ![]() Install the x86_64 version of Homebrew if you don't already have it. All subsequent commands should be run within this shell. Open Terminal (search in Spotlight on macOS).Įnter an x86_64 shell to continue the following steps in a Rosetta environment. You may follow the steps at the end of this section after installing Brew to achieve this. zshrc file to allow either version to be used depending on the active architecture. If you prefer to keep both ARM64 and x86 versions of brew installed, you may add a "brew-switcher" to your. Either use a Homebrew uninstall script or delete the folder /opt/homebrew/bin. Note: if you have ever installed Homebrew before, then it is advised to remove ARM64 Homebrew as this can interfere with this build process. opt/local/libexec/game-porting-toolkit/bin/wine64 Īnd gameportingtoolkit itself should be in path and if not its under Keep in mind instead of brew -prefix you will need to replace it with the wine from macports path, Next you install the porting toolkit itself and you should be good to move onto the Wine Prefix section in this guide, keep in mind it might fail the first time or two, but it might just need a retry if it still doesn't work after a couple tries please report issues to sudo port install game-porting-toolkit Sudo port install game-porting-toolkit-d3dmetal If you want install under Macports here is the guideįollow this guide to configure the local repository then syncįirst install game-porting-toolkit-d3dmetal, it will fail at first, follow the steps it gives you which tells you where to put the game porting toolkit dmg Open/mount the dmg file (some commands will require that it is mounted). Search for Game Porting Toolkit and download it. ![]()
![]() One of Keep's most powerful features is its native integration with Google's cross-platform reminder system. ![]() You can also empty your trash manually while you're there, in case you ever delete something sensitive and want to make sure it's completely gone. That'll let you see every deleted note from the past seven days and optionally restore any item into active status, if you're so inclined. Just tap the three-line menu icon in the app's upper-left corner and then select Trash from the panel that appears. Make a mental note: If you ever can't find a recent note, take a peek in Keep's Trash section to see if it might have gotten deleted by accident. You can also browse through your notes by label by tapping the three-line menu icon in the app's upper-left corner and then selecting whichever label you want to view. Keep's search function has ample options for filtering your notes to help you find what you need. Among other things, you'll see tools for filtering your notes to show only those with reminders, lists, images, or URLs attached as well as only notes assigned to a particular color or label. Tap the search box at the top of the app's main screen and then scroll down a bit. Speaking of search, Keep's search function can do a lot more than just look for basic text. Whichever way you do it, that'll archive the note - and just like in Gmail, it'll then remain easily accessible via search or browsing but won't command prime real estate and clutter up your "inbox." 5. ![]() When a note no longer needs your immediate attention, get it out of your main note list by swiping it toward the left or the right from that view - or by tapping the archive icon (a folder with a down-pointing arrow on it) in the upper-right corner while you're editing it. (To unpin a note at any time, just tap its pushpin icon again.) 4. That note will then appear in a special "Pinned" section above all your other notes so it's never out of reach. Keep your most important notes easily accessible by embracing Keep's pin function: Just tap the pushpin icon in the upper-right corner while editing a note or after selecting it in your main note list. From the main list view, you can also select any note (or combination of notes) and then tap the palette icon in the upper-right area of that screen. To change a note's color, tap the three-dot menu icon in the lower-right corner of the editing screen and then touch whatever color you want to apply. You can come up with any number of systems to make the colors useful either on their own or in conjunction with the regular text labels. Maybe all of your work-related notes are green and your personal notes are blue - or maybe urgent notes are red while all others are gray. In addition to labels, Keep lets you organize notes by color. The Keep app will suggest labels as soon as you type a hashtag - and once you've selected a label, you'll see it beneath your text. Keep will even pop up suggestions for existing labels as soon as you start typing, and once you've selected the label you want, you can either leave your hashtag text in the note or erase it. (You can select multiple notes at once, too: Just touch and hold any note until it becomes outlined, then tap any other notes to add them into the mix.)įaster yet, you can actually type a label directly into a note by prefacing it with a hashtag - "#Personal," "#Web Projects," or "#Business Ideas," for example. You can add a label to a note by tapping the three-dot menu icon in the lower-right corner of the app's editing screen and selecting "Labels" - or by touching and holding a note in the main list view and then tapping the label icon in the upper-right corner of that screen. Just like Gmail, Keep relies on labels rather than folders or notebooks to make your memos manageable. A few menu choices are slightly different, but it should be easy enough to figure things out if you or anyone you know prefers that style of device.) Part I: Organization 1. (A quick side note, by the way: My editor, who uses an iPhone (gasp!), says all these tips work pretty much the same in the Keep app for iOS. ![]() I hope it goes without saying, but feel free to jot down notes along the way. If you, too, rely on Google Keep to supplement your gray matter, check out these practical tips to make sure you're tapping into all the ways its Android app can act as your memory extension. ![]() 1/2/2024 0 Comments Shannon messenger child![]() ![]() That is because your beliefs, experiences, and priorities can change over time as the world changes around you (and not because the author suddenly announces character revisions over twitter). I'm sure that if you read the same books 10 years from now, you may interpret them differently. ![]() I think if you want to enjoy the story as told by the books, just focus on how you interpret it. Some believe that authors are like artists in that once their work is released to the public, their original intent is not relevant and all that matters is what readers interpret from the work. While I don't like some of what she put in her books, nothing was offensive or attacking others, and it is such a small part of her books that at the end of the day, the sections are short enough to move on quickly. However, I agree with other comments that talk about how the elven world really isn't perfect, as well as how she has to be careful with her artist and publishing company.Īlthough I am uncomfortable with what I have explained above and in my post, I agree that it's better to just enjoy the world. While I understand that just because Shannon doesn't have LGBTQ characters in her books doesn't mean she is homophobic, I am more concerned about the fact that matchmaking comments give no suggestion that homosexuality even exists. Forkle's discussion in Neverseen, it is true that many younger readers don't quite get it yet. ![]() I see your point, even though myself and probably many older readers didn't miss the double meaning of Sophie and Mr. I personally write a bit in my free time, but if I was a children's author, I probably would avoid including abortion/politics in my work. My post is more about the fact that I felt like she was trying to put her opinion on abortion/when life begins in a children's book. Judge the work by what is there, not by what isn't. It's a rigged game against a creator because there will always be someone else who doesn't feel represented. If every single work of fiction had to represent every minority type of person, the focus on representation would elbow out almost all other themes the author is trying to convey. I am also adamantly against the idea that lack of diversity in a work implies some bigotry from the author. If the work itself is good, just enjoy it and allow it to speak what it has to say, and at the very least you've gained a new perspective on things without losing something you love. People aren't evil because you disagree with them, and a fictional world isn't ruined because it doesn't align perfectly with your opinions. But even when I notice things in fiction that I don't agree with, I try not to see it as problematic or read anything sinister into it. With full disclosure, I am a conservative myself with pro-life views. I definitely noticed the pro-life implications of elven pregnancy when that came up in Neverseen. I can't imagine any author keeping their work and their views entirely separate, so I expect to see these things in any work of fiction and I enjoy a creative perspective on things, even if I don't agree with it, as long as it is thought-provoking. I love this series, but I feel like some of the things I've just discussed are problematic. I understand that the publishers of her books may just want her to avoid it to not lose fans, but as a reader, I have no way of knowing if this is true or if she genuinely has a problem with LGBTQ readers. I kind of get the vibes that because "elves are so perfect" that none of them aren't heterosexual, which creates the message that non-hetersexuality is a mistake. Honestly it makes me kind of uncomfortable reading that scene every time because it's so blatant and clear.Īlso, she's had characters talk about matchmaking several times where they, again, make it clear that only opposite-sex matching and marriage occur. I don't want to accuse Shannon of trying to force her beliefs on us, but I feel like she's trying to send a message to her (often quite young) readers. Forkle tells Sophie in Neverseen that her inception date is "the day your life began." Elves count their ages from conception, they never miscarry, and they seem to have an attitude that developing embryos/fetuses of elves are 100%, without a doubt, alive. The strongest thing I've really noticed are the comments that imply that she is pro-life. I honestly even feel guilty just typing that out I love these books and characters. ![]() ![]() ![]() ![]() If you wish to comment on product selection, pricing, ordering, delivery or other issues, please contact our customer service. We reserve the right to remove non-compliant reviews language. Personal information such as email addresses, phone numbers or physical addressesĪll reviews are subject to our Terms of Use.Advertising, spam, references to other websites or retailers.Critical or inappropriate comments about other reviews and shoppers Cheer Up Buttercup is an uplifting blend of five different essential oils that delivers a pleasing aroma to help brighten even the dullest day.Language referencing a state of disease (including but not limited to references to pain, aches, inflammation, medicine replacement, cancer, cold/flu, arthritis, depression, insomnia, etc.).To meet our publishing standards, please refrain from including the following in your review: Be sure to explain why you like or dislike the product and focus on the product's features. As someone who has used essential oils for a while now, I was excited to try NOW Foods Essential Oils Cheer Up Buttercup blend. NOW Solutions Cheer Up Buttercup Essential Oil Blend is great in a diffuser, or as a room spray when 30 drops are added to 1 oz. We value your input and look forward to hearing about your personal product experiences. NOW Essential Oils Cheer Up Buttercup Blend 30ml Bergamot Oil, Orange Oil, Lime Oil, Grapefruit Oil, and Lemon Oil Citrus with light herbal Uplifting. ![]() Reviews containing references to a state of disease (e.g., pain, aches, inflammation, medicine replacement, cancer, cold/flu, arthritis, depression, insomnia, etc.) cannot be published. ![]() ![]() ![]() KNO 3 will remain in solution since all nitrates are soluble in water. The products should rearrange the ions to: What would be the expected products and will a precipitate form? The resulting balanced reaction would be:Ģ AgNO 3(aq) + MgBr 2 → 2 AgBr(s) + Mg(NO 3) 2(aq) The other compound Mg(NO 3) 2 will remain in solution because all nitrates, (NO 3) -, are soluble in water. Are the products soluble in water?Īccording to the solubility rules, all silver salts are insoluble in water with the exception of silver nitrate, silver acetate and silver sulfate. The state of the products needs to be determined. The balanced reaction would be:Ģ AgNO 3(aq) + MgBr 2 → 2 AgBr(?) + Mg(NO 3) 2(?) For example, a silver nitrate solution (AgNO 3) is mixed with a solution of magnesium bromide (MgBr 2). The question remains, will AD or CB remain in solution or form a solid precipitate?Ī precipitate will form if the resulting compound is insoluble in water. This reaction is generally a double replacement reaction in the form: When two aqueous solutions are mixed, the ions interact to form products. These solutions are represented in chemical equations in the form: AB(aq) where A is the cation and B is the anion. This guide will show how to use the solubility rules for inorganic compounds to predict whether or not the product will remain in solution or form a precipitate.Īqueous solutions of ionic compounds are comprised of the ions making up the compound dissociated in water. Next, learn about the Effects of Acid Rain.When two aqueous solutions of ionic compounds are mixed together, the resulting reaction may produce a solid precipitate. The Long-Term Monitoring (LTM) Network measures and monitors surface water chemistry at over 280 sites to provide valuable information on aquatic ecosystem health and how water bodies respond to changes in acid-causing emissions and acid deposition. When acid deposition is washed into lakes and streams, it can cause some to turn acidic. Air concentrations are measured by CASTNET at more than 90 locations. Dry deposition estimates for nitrogen and sulfur pollutants are provided by the Clean Air Status and Trends Network (CASTNET). ![]() Unlike wet deposition, dry deposition is difficult and expensive to measure. The NADP/NTN collects acid rain at more than 250 monitoring sites throughout the US, Canada, Alaska, Hawaii and the US Virgin Islands. Policymakers, research scientists, ecologists, and modelers rely on the National Atmospheric Deposition Program’s (NADP) National Trends Network (NTN) for measurements of wet deposition. Acid rain usually has a pH between 4.2 and 4.4. Normal rain has a pH of about 5.6 it is slightly acidic because carbon dioxide (CO 2) dissolves into it forming weak carbonic acid. The lower a substance's pH (less than 7), the more acidic it is the higher a substance's pH (greater than 7), the more alkaline it is. For example, in desert areas the ratio of dry to wet deposition is higher than an area that receives several inches of rain each year.Īcidity and alkalinity are measured using a pH scale for which 7.0 is neutral. The amount of acidity in the atmosphere that deposits to earth through dry deposition depends on the amount of rainfall an area receives. When the accumulated acids are washed off a surface by the next rain, this acidic water flows over and through the ground, and can harm plants and wildlife, such as insects and fish. The acidic particles and gases may deposit to surfaces (water bodies, vegetation, buildings) quickly or may react during atmospheric transport to form larger particles that can be harmful to human health. Dry DepositionĪcidic particles and gases can also deposit from the atmosphere in the absence of moisture as dry deposition. The sulfuric and nitric acids formed in the atmosphere fall to the ground mixed with rain, snow, fog, or hail. Wet deposition is what we most commonly think of as acid rain. Winds can blow SO 2 and NO X over long distances and across borders making acid rain a problem for everyone and not just those who live close to these sources. Manufacturing, oil refineries and other industries.Two thirds of SO 2 and one fourth of NO X in the atmosphere come from electric power generators. ![]()
1/2/2024 0 Comments Vagrus discord![]() It is important to know that no new UI or feature comes with the outpost, since Vagrus is not a game that involves building stuff - the outpost is instead presented in Event format like it was envisioned from the beginning (and similar to other victory paths). This means that you can now build your own outpost out in the wasteland (one specific spot for now, room for expansion later), and upgrade it bit by bit so that in the end it yields you profit from time to time if managed properly. Although some bugs are still being hunted, the latter two are now being added to Vagrus. We've been trying to catch up since the launch last Tuesday and get on top of some of the bugs that many of you reported while also rounding out the missing Outpost and Wealth victory path ending parts. ![]() Appreciate it!įig.A New Build is OUT - Patch 1.01 - Codename: Outpost Wanna get the game as early as possible with even more content? Please share our pages and posts with your friends through your favorite social media channel(s). Get instant access to the Alpha build now! Our crowdfunding campaign is LIVE at Fig.co. We'll discuss them in more detail in a future post, so stay tuned! Some of them you have already encountered when playing the Open-world campaign, like the Church of Sergorod, the Ratharnak Alliance, the furtive Abolitionists, or one of the Imperial Trading Houses. There are 11 factions currently in game, though several of them are partially implemented and will be fleshed out more with upcoming content patches. For now, trade Tasks will be implemented. As far as factions are concerned, they are closely tied to them: only factions can give you Tasks, depending on how well they like you. There is a post that deals with them in more detail here. Tied to specific factions, Tasks can be trade contracts, mercenary jobs, or exploration missions. Task are randomly generated missions that allow players to level up their faction reputations. Most factions have a presence in large cities, though. Faction presence is also varied, with headquarters allowing for the most interaction. ![]() You can check your standing with all factions here as well as what each tier provides, read about factions, and check on their allies and enemies.Īpart from that, factions also appear on the settlement UI, where Tasks can be taken, turned-in, and rewards are redeemed, provided the faction in question is present in the given settlement. First and foremost, factions appear as a separate UI tab under the Leader main UI (since faction relations belong to your character the vagrus). There are several places where you can find factions on already existing UI elements. Most factions also provide quests and other content with the right tier unlocked. You can absolutely lose standing, which results in losing the passive benefits of that tier (although not the already possessed rewards). Factions are often at odds with each other, so gaining reputation with one might lower reputation with another or two. Enough points unlock tiers of faction standing that award the player with all kinds of goodies: discounts, items, equipment, and better paying Tasks, to name a few. In short, factions are organizations you can gain reputation with. With Tasks being implemented and so intimately intertwined with factions, we thought we'd give you a rundown of what to expect from the next large addition to the game. ![]() They are currently in the game and can be interacted with one way or the other but there is no UI to track your standing with them, nor is it possible to claim rewards for each unlocked reputation tier (although there are already a lot of implicit benefits and rewards for high reputation with almost every faction). We have long been talking about improving the experience with factions in Vagrus. ![]() 1/2/2024 0 Comments Polio outbreak![]() The most recent detection of the previously described NIE-KGS-1 emergence was through environmental surveillance in January 2020 ( 1, 3).ĭuring July–September 2019, the NIE-SOS-7 emergence was detected through environmental surveillance in Nigeria circulation was confirmed after the previous global update ( 3). Since first detected, genetically linked virus has circulated in 17 west and central African countries, from Mauritania to Cameroon during the reporting period circulation was documented in 16 of the 17 countries (excluding Cameroon) resulting in 310 cases of cVDPV2 in 14 countries and detection through environmental surveillance in 13 countries ( 1, 3). The previously described cVDPV2 emergence (NIE-JIS-1) ( 1, 3), first detected in Nigeria in 2018, continued to circulate during the reporting period. No polioviruses genetically linked to two previously described emergences (CHN-XIN-1 and ZAM-LUA-1) have been detected since 2019 ( 1, 3). During the reporting period, fifteen (58%) of the 26 emergences in active transmission in African countries were detected, either in AFP patients or through environmental surveillance, outside of the country of first isolation of genetically linked virus ( Figure 2). Nineteen (50%) of the 38 emergences were previously detected during 2017–2019, three (8%) (ETH-ORO-4, ETH-SOU-2, and NIE-SOS-7) were newly detected in 2019 but were confirmed after the last global report, and 16 (42%) were newly detected during 2020–2021 ( 1, 3). A goal of the Global Polio Eradication Initiative’s (GPEI) 2022–2026 Strategic Plan is to better address the challenges to early CVDPV2 outbreak detection and initiate prompt and high coverage outbreak responses with available type 2 OPV to interrupt transmission by the end of 2023 ( 8).ĭuring January 2020–June 2021, there were 38 cVDPV2 emergences in active transmission in 34 countries 28 (82%) of these countries are in Africa (Table) (Figure 1). The number of cVDPV2 cases increased from 366 in 2019 to 1,078 in 2020 ( 7). During this period, there were 44 cVDPV outbreaks of the three serotypes affecting 37 countries. This report updates that of July 2019–February 2020 to describe global cVDPV outbreaks during January 2020–June 2021 (as of November 9, 2021) † ( 3). ![]() In October 2021, the Strategic Advisory Group of Experts on Immunization (WHO’s principal advisory group) permitted wider use of nOPV2 however, current nOPV2 supply is limited ( 6). In November 2020, the World Health Organization (WHO) Emergency Use Listing procedure authorized limited use of type 2 novel OPV (nOPV2), a vaccine modified to be more genetically stable than the Sabin strain, for cVDPV2 outbreak response ( 3, 5). ![]() ![]() Since the switch, monovalent OPV type 2 (mOPV2, containing Sabin strain type 2) has been used for response to cVDPV type 2 (cVDPV2) outbreaks tOPV is used if cVDPV2 co-circulates with WPV type 1, and bOPV is used for cVDPV type 1 (cVDPV1) or type 3 (cVDPV3) outbreaks ( 1– 4). Circulating vaccine-derived poliovirus (cVDPV) outbreaks* occur when transmission of Sabin strain poliovirus is prolonged in underimmunized populations, allowing viral genetic reversion to neurovirulence, resulting in cases of paralytic polio ( 1– 3). ![]() As of May 1, 2016, use of oral poliovirus vaccine (OPV) type 2 for routine and supplementary immunization activities ceased after a synchronized global switch from trivalent OPV (tOPV containing Sabin strain types 1, 2, and 3) to bivalent OPV (bOPV containing Sabin strain types 1 and 3) subsequent to the certified eradication of wild type poliovirus (WPV) type 2 in 2015 ( 1– 3). ![]() |
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